Kazakhstani Neurosurgeon Galymzhan Issabekov on Brain Research in Berlin

In an era of globalization, science has become an increasingly borderless field dedicated to advancing human well-being. This is especially evident in neuroscience, where ongoing discoveries are deepening understanding of the human brain, one of the body’s most complex and least understood organs, while shaping the future of medicine. Among the emerging researchers in this field is Kazakhstani neurosurgeon and PhD scholar Galymzhan Issabekov. Issabekov is part of a new generation of scientists building international careers in research and medicine. His academic path began at Peking University, where he received medical training and developed a strong foundation in research. He later completed a residency in functional neurosurgery in Beijing, combining clinical practice with scientific work and focusing in particular on hemispherectomy, a complex procedure used to treat severe pediatric epilepsy. [caption id="attachment_46916" align="aligncenter" width="300"] From G.Issabekov's personal archive[/caption] Seeking further professional development, Issabekov continued his training in Japan. With support from the Takeda Science Foundation, he joined Tokyo Women’s Medical University as a fellow, working alongside neurosurgeon Professor Takaomi Taira. This period was instrumental in shaping his research interests and integrating him into the international scientific community. He is currently based in Berlin, where he conducts research at Charité University Hospital. His work focuses on improving deep brain stimulation (DBS), an advanced therapy used to treat Parkinson’s disease. The procedure involves implanting electrodes in deep brain structures to regulate abnormal neural activity. As Issabekov explains, some DBS procedures are performed while the patient is conscious. During these operations, neurophysiologists monitor electrical brain activity in real time, providing neurosurgeons with highly precise, navigation-like guidance. This enables the accurate placement of electrodes in extremely small regions such as the subthalamic nucleus. Experienced specialists can even identify these areas through the distinct patterns, or “sounds,” of neuronal signals, reflecting a high level of surgical precision. Together with his colleagues, Issabekov is developing a new intraoperative protocol that allows for simultaneous brain stimulation and real-time monitoring of neural responses. Previously, combining these processes posed significant technical challenges. The new method is expected to offer deeper insight into the mechanisms of DBS and support more individualized treatment approaches. The research team has reached an important stage, with initial findings now being prepared for publication. Early results indicate strong potential for meaningful scientific advances. Despite working abroad, Issabekov maintains close ties with Kazakhstan’s academic community. He is co-founder and vice president of the Global Central Asian Science and Technology (CAST) Association, which connects more than 150 researchers from Kazakhstan and across Central Asia in over 30 countries. The organization supports early-career scientists by facilitating international placements and promoting global collaboration. “Many Kazakh researchers abroad are willing to contribute to the development of science in their home country,” Issabekov said. “What has been missing is a structured platform to connect them. Our association aims to fill that gap. We also help participants in the Bolashak program, particularly within the '500 Scientists’ initiative, find suitable research institutions and laboratories overseas.” Beyond his scientific work, Issabekov highlights a broader...

Kazakh Researchers Uncover Important Step Towards Treating Parkinson’s Disease

Kazakhstan’s reputation in the global scientific community is evolving, thanks to research conducted by local scientists. Aizhan Ahmadi, a doctoral graduate from Nazarbayev University’s (NU) School of Natural, Social, and Human Sciences, and her team have made a discovery that could pave the way for future treatments for Parkinson’s disease. TCA: Tell us about your research. Aizhan: I recently completed my doctoral studies, defended my dissertation, and earned my PhD. Before that, I worked at a university for five years. During my research, I focused on a mutated protein called DJ-1, which is found in patients with Parkinson’s and Alzheimer’s diseases. More than 20 years ago, European scientists identified mutations in DJ-1 in some patients suffering from these diseases. Despite extensive research in dozens of laboratories, the protein’s exact role remained unclear. While analyzing previous studies, we came across a large European research project with an interesting hypothesis about DJ-1. We decided to explore this direction further and we succeeded in proving that DJ-1 has a previously unknown function. Understanding how DJ-1 protects biomolecules is not only crucial for developing new treatment methods for Parkinson’s disease but also for explaining cell aging. This discovery is vital for pharmacologists, as they cannot develop effective drugs without fully understanding a protein’s function. For the first time, we have proven a new function of DJ-1. I believe this is a fundamental breakthrough for both global science and Kazakhstan’s scientific community. We submitted our findings to Nature Communications, a leading scientific journal. After a rigorous eight-month review process, our research was accepted. This was a difficult but rewarding journey. Our study is the first from independent Kazakhstan to be published in such a prestigious journal, making it a landmark achievement for our country. TCA: What challenges come with studying biology in Kazakhstan? Aizhan: Basic biological research is extremely resource-intensive. It takes time, energy, and has no guaranteed results. We invested grant funding and used millions of dollars’ worth of equipment. However, when a discovery is made, its contribution to science and medicine is invaluable. Our study was conducted entirely within Kazakhstan, without relying on foreign laboratories. This is particularly significant because many still doubt whether serious scientific breakthroughs can come from Kazakhstan, especially in biochemistry. Alongside me, my supervisor, Darkhan Utepbergenov, and several undergraduate students participated in the research. Professor Utepbergenov, a Kazakhstani scientist, graduated from Novosibirsk State University, worked in Germany and the U.S. for nearly 20 years, and then returned to Kazakhstan as a professor. He has said that this is his most significant work to date, and even he still finds it hard to believe that such a discovery was made in Kazakhstan. His contribution to both research and teaching at Nazarbayev University has been immense. TCA: As a young woman in science, what motivated you to pursue this path? How can Kazakhstan raise the status of scientists? Aizhan: First and foremost, better financial support is essential. Salary structures need improvement, bureaucratic obstacles must be reduced, and science communication should be...