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Kazakh Scientists Unveil Advanced Organ Storage Technology at Expo 2025

A team of Kazakhstani doctors from the UMC Heart Center, led by renowned cardiac surgeon Yuri Pya, presented a groundbreaking development at the World Expo 2025 in Osaka, Japan: ALEM, a device designed for long-term preservation of donor organs. Developed with the support of the Heart Center Foundation, ALEM (Astana Life Ex-situ Machine) addresses a pressing issue in Kazakhstan’s vast geographical context, ensuring timely and effective delivery of donor organs across long distances. Extending the Viability of Life The ALEM device can keep a donor heart viable for more than 24 hours by replicating conditions inside the human body, including maintaining precise temperature, oxygen levels, and vital functions. This significantly extends the traditional preservation window of 4-6 hours, offering new potential for transplantation logistics and success rates. From Emergency to Innovation The idea for ALEM was born from necessity. As Pya recalls, “We had a difficult situation, due to weather conditions we couldn’t get a donor heart in time. Then the idea arose to create our own system, more affordable and perhaps even more effective.” The device was developed through interdisciplinary collaboration among cardiac surgeons, anesthesiologists, and engineers. It has already passed preclinical trials on animals and is now preparing for the next phase: clinical testing. More Than Preservation According to Timur Lesbekov, director of the Heart Center’s cardiac surgery department, ALEM offers not only preservation but also therapeutic potential. “This product can be called a breakthrough. To sustain an organ for more than a day is a great achievement. Importantly, the system can also treat organs before transplantation,” he said. Developers hope that showcasing ALEM at Expo 2025 will attract international attention and foster collaboration in the field of transplantology. “This is a historic moment for Kazakhstan,” said Murat Zauyrov, director of the Heart Center Foundation. “It’s the first time we are presenting a major medical innovation on such a global stage. Our aim is to contribute to global medical progress.” Kazakhstan’s Transplant Challenges Kazakhstan currently needs around 10 transplants per million residents annually, according to Pya. Since 2012, 100 heart transplants have been performed, a modest number, but each representing a life saved. “It’s not just a surgery. It’s a complex operation involving air ambulances, police, and coordination across at least five ministries,” he emphasized. Plans are underway to begin serial production of the ALEM device in Astana, which would position Kazakhstan among a select group of countries with a domestically developed system for long-distance organ transport. Expo 2025: A Global Stage for Innovation Expo 2025 in Osaka features participation from 158 countries and nine international organizations. ALEM is on display at the Kazakhstan Pavilion in the “Connecting Lives” zone under the broader theme “Creating a Future Society for Our Lives”. Kazakhstan’s pavilion, designed in the shape of a traditional shanyrak, was presented alongside exhibitions from South Korea, Germany, and Turkey. The opening ceremony was attended by Japanese Emperor Naruhito and Prime Minister Shigeru Ishiba, with Kazakhstan’s delegation led by Minister of Trade Arman Shakkaliev.

Women Empowerment Innovation Science Women Changing the World Awards Ophthalmology

Tajik Ophthalmologist Parvina Mirakhmedova Wins Innovation Award in London

Parvina Mirakhmedova, a Tajik ophthalmologist and researcher, has won international acclaim at the prestigious Women Changing the World Awards, held in London. She was the only representative from Central Asia among participants from 55 countries. Mirakhmedova was nominated in three Industry Award categories: Women in Health, Tech Innovation, and Innovation. She won the Tech Innovation Award and took second place in the Women in Health category. Sarah Ferguson, the Duchess of York, personally presented Mirakhmedova with the Golden Heart Award, honoring both her professional accomplishments and the broader social impact of her work. In her acceptance speech, Mirakhmedova expressed gratitude to those who supported her journey to London, emphasizing the importance of showcasing Tajikistan's scientific talent on the global stage. Transforming Ophthalmology with Innovation Over recent years, Mirakhmedova has significantly advanced the field of ophthalmology. She developed a new diagnostic algorithm for early-stage glaucoma detection, dramatically lowering the risk of vision loss. Additionally, she created cell-counting software that has standardized the diagnosis of ocular inflammation, notably improving treatment accuracy for uveitis. Her work has been published in peer-reviewed journals indexed in Scopus. Among her most accessible innovations is a Telegram bot (@ophthalmo_test_bot) that helps doctors monitor inflammation in uveitis, enabling timely treatment adjustments. Personal Struggles Behind the Science Mirakhmedova’s professional journey is rooted in personal adversity. “I lost my father to cancer, and later, my mother became seriously ill. I experienced first hand what patients and their families endure,” she said. These experiences inspired her to drive change in Tajikistan’s medical system. She advocates for the integration of global medical innovations, asserting, “The world is moving forward, innovations are transforming medicine, and Tajikistan must not fall behind.” A Decade of Determination Mirakhmedova began her career at the international Solim Med and private Nurafzo clinics and underwent further training in Germany. Initially, her ideas were met with skepticism. “Innovations are always resisted at first. But eventually, they become indispensable,” she noted. Despite early challenges, she remained committed to her vision, bolstered by support from her mentors at the Abuali Ibni Sino Department of Ophthalmology at the Tajik State Medical University, her family, and her own perseverance. Reaching the award finals marked a turning point. “I felt a deep sense of satisfaction. To those who once said my ideas were useless, this is the answer,” she said. Her recognition in London is not just a personal triumph, it affirms her contributions to medicine on an international scale and signals the potential for transformative change in ophthalmology across the region.

Scholars Ancient Civilizations Language Science

Scientists of Ancient Central Asia Still Relevant in the Modern World; The Idea of the Averaged Turkic Language

There is a debate on social media between Uzbek and Tajik communities about the medieval scholar Ibn Sina. The discussion revolves around the question of nationality — was Ibn Sina Tajik, Uzbek, or something else? Similar debates have emerged about other medieval scholars, including Al-Farabi. Ibn Sina (commonly known in the West as Avicenna) and Al-Farabi were two of the most influential scholars of the Islamic Golden Age. Ibn Sina, known for his contributions to medicine, philosophy, and science, wrote The Canon of Medicine, a foundational text in medical education for centuries. First published in 1025, his work stood as the standard medical textbook in Europe from its translation into Latin in the twelfth century through to the 1650s. Al-Farabi, often called the Second Greatest Teacher after Aristotle, made significant contributions to philosophy, logic, and political theory, shaping intellectual thought in the Islamic world and beyond. To explore this further, TCA spoke with two scholars — Fakhriddin Ibragimov, PhD, and Dr. Bakhtiyor Karimov — who have studied the lives and works of Ibn Sina and Al-Farabi extensively. [caption id="attachment_30258" align="aligncenter" width="1280"] Fakhriddin Ibragimov; image courtesy of the subject.[/caption] Fakhriddin Ibragimov, a researcher at the Abu Rayhan Biruni Institute of Oriental Studies, has spent nearly 15 years studying Ibn Sina. According to Ibragimov, historical sources provide no direct evidence of Ibn Sina’s nationality. “Ibn Sina (980 – 1037) was born in the village of Afshona, near Bukhara. Nowhere in his works or those written by his contemporaries is his nationality mentioned,” Ibragimov told TCA. “However, he is identified as a Muslim, like most people in Central Asia at the time. Also, many manuscript sources indicate that he was from Bukhara.” Ibragimov explains. Ibragimov also highlights that Ibn Sina himself wrote about his upbringing, describing how he was raised in an intellectual environment where philosophical and religious discussions were common: “We had a lot of scientific discussions, debates, and gatherings at home. Issues of faith were also raised there. My father and brother adhered to the Ismaili faith [one of the religious movements in Islam that was widespread in the Near and Middle East in the 10th and 11th centuries], but I did not join them,” Ibn Sina wrote. However, he did not mention any ethnic identity in his works or in those written by his contemporaries. [caption id="attachment_30260" align="aligncenter" width="575"] Avicenna at the sickbed, miniature by Walenty z Pilzna, Kraków (ca 1479–1480); image: jbc.bj.uj.edu.pl[/caption] The claim over Ibn Sina’s legacy is widespread. While Uzbeks and Tajiks both regard him as one of their own, Iranians also consider him Persian due to the language of his writings. In 2018, a bust of Abu Ali Ibn Sina was installed in front of the campus of the Autonomous University of Madrid as a gift from the Iranian embassy. The inscription on the bust reads, “Persian physician and philosopher.” Even Jewish scholars have cited him as part of their intellectual heritage. However, Ibragimov argues that Ibn Sina should be seen as a global figure rather...

Science TCA Interviews Biology Parkinson's disease

Kazakh Researchers Uncover Important Step Towards Treating Parkinson’s Disease

Kazakhstan’s reputation in the global scientific community is evolving, thanks to research conducted by local scientists. Aizhan Ahmadi, a doctoral graduate from Nazarbayev University’s (NU) School of Natural, Social, and Human Sciences, and her team have made a discovery that could pave the way for future treatments for Parkinson’s disease. TCA: Tell us about your research. Aizhan: I recently completed my doctoral studies, defended my dissertation, and earned my PhD. Before that, I worked at a university for five years. During my research, I focused on a mutated protein called DJ-1, which is found in patients with Parkinson’s and Alzheimer’s diseases. More than 20 years ago, European scientists identified mutations in DJ-1 in some patients suffering from these diseases. Despite extensive research in dozens of laboratories, the protein’s exact role remained unclear. While analyzing previous studies, we came across a large European research project with an interesting hypothesis about DJ-1. We decided to explore this direction further and we succeeded in proving that DJ-1 has a previously unknown function. Understanding how DJ-1 protects biomolecules is not only crucial for developing new treatment methods for Parkinson’s disease but also for explaining cell aging. This discovery is vital for pharmacologists, as they cannot develop effective drugs without fully understanding a protein’s function. For the first time, we have proven a new function of DJ-1. I believe this is a fundamental breakthrough for both global science and Kazakhstan’s scientific community. We submitted our findings to Nature Communications, a leading scientific journal. After a rigorous eight-month review process, our research was accepted. This was a difficult but rewarding journey. Our study is the first from independent Kazakhstan to be published in such a prestigious journal, making it a landmark achievement for our country. TCA: What challenges come with studying biology in Kazakhstan? Aizhan: Basic biological research is extremely resource-intensive. It takes time, energy, and has no guaranteed results. We invested grant funding and used millions of dollars’ worth of equipment. However, when a discovery is made, its contribution to science and medicine is invaluable. Our study was conducted entirely within Kazakhstan, without relying on foreign laboratories. This is particularly significant because many still doubt whether serious scientific breakthroughs can come from Kazakhstan, especially in biochemistry. Alongside me, my supervisor, Darkhan Utepbergenov, and several undergraduate students participated in the research. Professor Utepbergenov, a Kazakhstani scientist, graduated from Novosibirsk State University, worked in Germany and the U.S. for nearly 20 years, and then returned to Kazakhstan as a professor. He has said that this is his most significant work to date, and even he still finds it hard to believe that such a discovery was made in Kazakhstan. His contribution to both research and teaching at Nazarbayev University has been immense. TCA: As a young woman in science, what motivated you to pursue this path? How can Kazakhstan raise the status of scientists? Aizhan: First and foremost, better financial support is essential. Salary structures need improvement, bureaucratic obstacles must be reduced, and science communication should be...

Science Heritage History research

Mukhamedzhan Tynyshpaev: Pioneer, Patriot, and Kazakh Visionary

Mukhamedzhan Tynyshpaev, a Kazakh scholar, politician, and visionary, has returned to the spotlight with the publication of his book The History of the Kazakh People in Kazakhstan. This book, originally written in Russian in 1925 under the title Materials on the History of the Kyrgyz-Kazakh People, was republished in Kazakh in 2023 by AmalBooks. The work explores the origins of the Kazakh tribes, the development of Kazakh statehood, and the nation’s rich history. Tynyshpaev was a towering figure in Kazakh history. Born on May 12, 1879, in the Lepsinsky district of Semirechyenskaya Oblast, he rose to prominence as one of the founders of the Alash movement. Beyond his roles as a historian and scholar, he was Kazakhstan’s first railway engineer, a deputy in the Second State Duma of the Russian Empire, and a leading contributor to the construction of the Turkestan-Siberian Railway. He also served briefly as deputy chairman of the Alash Autonomy government. The Central State Archive of Kazakhstan preserves three unique photographs that capture moments from Tynyshpaev’s extraordinary life. The first photograph, dated around 1900, shows a young Tynyshpaev as a student of the Imperial Institute of Railway Engineers in St. Petersburg, where he studied from 1900 to 1905. This image, taken at the Leibin and Sons photo studio in Verny (now Almaty), reflects his early academic promise. In the second photograph, Tynyshpaev is seen among representatives of the Kazakh student intelligentsia studying at universities in St. Petersburg (he is seated third from the left). The archive dates the document between 1903 and 1909 and includes the following caption: "Dosmukhamedov Kh. (third row, third from the left) - student of the Imperial Military Medical Academy of St. Petersburg; Tynyshpaev M. (second row, second from the right) - student of the Imperial Institute of Railway Engineers named after Alexander I with fellow countrymen." Upon studying this document, we identified Zhansey (Zhihansha) Alimuratovich Seydalin — a student of the Faculty of Law at St. Petersburg University (third row, second from the left). He later became a public figure, lawyer, and member of the national Alash party. Also present in the photograph is the first Kazakh woman to receive higher education at St. Petersburg universities — Gulsum Asfendiyarova (second row, left). Today, Gulsum Asfendiyarova is known as the first Kazakh female doctor with a higher education, an organizer of the healthcare system in the Turkestan region, a medical educator, and the elder sister of Sanjar Asfendiyarov — a renowned doctor, political figure, scholar, and professor, after whom the medical university in Almaty is now named. Mukhamedzhan Tynyshpaev studied at the Imperial Institute of Railway Engineers in St. Petersburg from 1900 to 1905. Kh. Dosmukhamedov studied at the Imperial Military Medical Academy in St. Petersburg from 1903 to 1909. Zh. Seydalin studied at St. Petersburg University from 1900 to 1904. Asfendiyarova studied at the Women’s Medical Institute in St. Petersburg from 1902 to 1908. Based on these facts, it can be assumed that the photograph was taken in 1903 or 1904 when all the mentioned...

Science Invention Gold Medal International Inventors Forum

Tajik Scientist Kholikzoda Wins Gold Medal at International Inventors Forum

Tajik scientist Omina Kholikzoda has won a gold medal at the 15th International Invention Fair of the Middle East, held in Kuwait. Kholikzoda, a researcher at the Ibn Sina Tajik State Medical University's Institute of Fundamental Medicine, was awarded for her discovery, a preparation called Tagetol, derived from the essential oil of small-flowered tagetes, a plant native to Tajikistan. Tagetol has strong hepatoprotective, choleretic, antioxidant, detoxifying, and anti-inflammatory properties. The International Invention Fair of the Middle East, established in 1974, is considered one of the world’s largest platforms for showcasing scientific achievements. This year’s event featured participants from 66 countries, highlighting cutting-edge research and technological advancements. Five scientists from Tajikistan took part in the forum, but it was Kholikzoda’s work that stood out, receiving top recognition from the jury. Kholikzoda’s success at the international level underscores Tajikistan’s growing presence in scientific research and innovation.